Optimization of synthetic route to PNA-T-OH monomers
نویسندگان
چکیده
منابع مشابه
Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry
Progress in genome research led to new perspectives in diagnostic applications and to new promising therapies. On account of their specificity and sensitivity, nucleic acids (DNA/RNA) increasingly are in the focus of the scientific interest. While nucleic acids were a target of therapeutic interventions up to now, they could serve as excellent tools in the future, being highly sequence-specific...
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15 صفحه اولSynthesis and oligomerization of Fmoc/Boc-protected PNA monomers of 2,6-diaminopurine, 2-aminopurine and thymine.
A Boc-protecting group strategy for Fmoc-based PNA (peptide nucleic acid) oligomerization has been developed for thymine, 2,6-diaminopurine (DAP) and 2-aminopurine (2AP). The monomers may be used interchangeably with standard Fmoc PNA monomers. The DAP monomer was incorporated into a PNA and was found to selectively bind to T (ΔT(m)≥ +6 °C) in a complementary DNA strand. The 2AP monomer showed ...
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ژورنال
عنوان ژورنال: Journal of the Turkish Chemical Society, Section A: Chemistry
سال: 2018
ISSN: 2149-0120
DOI: 10.18596/jotcsa.380410